Keywords spinosyns;Saccharopolyspora spinosa;HPLC;rational selection;precursor;fermentation optimization;spinosyns resistant mutant;rhamnose resistant mutant;2-deoxygen-D-glucose resistant mutant;

• 多杀菌素;刺糖多孢菌;HPLC;推理选育;前体;发酵培养基优化;多杀菌素抗性变株;鼠李糖抗性变株;2-脱氧-D-葡萄糖抗性变株;